Researchers at the ChristianaCare Gene Editing Institute used CRISPR to disable the NRF2 gene in lung cancer cells, restoring sensitivity to chemotherapy. Their results — published in Molecular Therapy Oncology — show that tumors with NRF2 knocked out grow slower and respond more strongly to drugs like carboplatin and paclitaxel. This approach could provide a powerful new tool for overcoming drug resistance in cancer therapy, improving outcomes for patients whose tumors have become tolerant to conventional treatments.
Source: Business Wire / Press Release
Link: https://www.businesswire.com/news/home/20251114585351/en/ChristianaCare-Gene-Editing-Institute-Achieves-CRISPR-Breakthrough-That-Reverses-Chemotherapy-Resistance-in-Lung-Cancer
CRISPR Gene Editing Reverses Chemotherapy Resistance in Lung Cancer
Summary:
Share This Article
- The “VECTOR” Procedure: First Minimally Invasive Coronary Bypass Performed
The procedure, called ventriculo-coronary transcatheter outward navigation and re-entry, or VECTOR, creates a new route for blood flow that is a safe distance away from the aortic valve. - World’s Smallest Autonomous Programmable Robots Created by Penn & Michigan Engineers
Engineers have built the smallest fully autonomous robots yet, capable of sensing, computing, and acting on their own at microscopic scales, with potential applications in medicine and manufacturing. - The Southern Origin: Ancient Genomes Reveal Proto-Austronesian Migration Paths
Through the genome-wide data of 26 ancient human remains from northern and southern East Asia, spanning 9,500 to 300 years ago, including some extracted from the Qihedong skull, they carried out a series of scientific analyses that supported a southern China origin for proto-Austronesians. - Genetic Time Travel: First Ancient Human Herpesvirus Genomes Reconstructed
The findings trace the long history of HHV-6 integration into human chromosomes and suggest that HHV-6A lost this ability early on… trace the viruses’ evolution can now be traced over more than 2,500 years across Europe, using genomes from the 8th-6th century BCE until today. - Scientists Identify Two New Biological Subtypes of Multiple Sclerosis
Scientists have identified two new biological subtypes of multiple sclerosis using AI, blood biomarkers, and MRI scans. The discovery could lead to more accurate diagnoses and personalized treatments based on how the disease damages the nervous system.
Leave a Reply