Regeneron and Tessera Therapeutics announced a $150 million collaboration to develop TSRA-196, an investigational “Gene Writing” therapy for alpha‑1 antitrypsin deficiency (AATD). The approach aims to correct disease-causing variants and durably restore functional AAT production using Tessera’s retrotransposon-based editor with nonviral delivery. The partners plan near‑term IND and CTA filings, positioning the program to enter clinical testing as part of a broader pipeline of precision genetic medicines. If successful, a one‑time gene edit could obviate chronic augmentation therapy, reducing lifelong treatment burdens. The deal underscores pharma’s appetite for modular editing platforms that can be adapted to multiple monogenic diseases and highlights investment momentum in respiratory and hepatic genetic disorders.
Source: BioXconomy (Dec 3, 2025)
Link: https://www.bioxconomy.com/partnering/regeneron-and-tessera-ink-150m-deal-to-develop-aatd-gene-therapy
Regeneron and Tessera Partner on $150M Gene Editing Therapy for AATD
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